12 MINIREVIEW Current Prospects for the Fluoroquinolones as First-Line Tuberculosis Therapy Howard Takiff* and Elba Guerrero Instituto Venezolano de Investigaciones CientÃ?cas (IVIC), Caracas, Venezuela and by adding various side groups literally thousands of distinct ?uoroquinolones were synthesized. Although the increase broad-spectrum activity of cipro?oxacin (CIP) created the expectation that it would be a expensive agent against troublesome bacteria such as staphylococcus aureus, unsusceptibilit! y in these bacteria developed rapidly. Within exactly a few years after the introduction of CIP, some(prenominal) nosocomial strains (9) were resistant (10), especially Gram-positive bacteria. In contrast, CIP has remained in effect(p) much time-consuming against some enteric Gramnegative bacteria, such as Escherichia coli (49). The difference appeared to be relate to the ratio of the usual serum drug concentration to the innate MIC of the bacteria. The...If you trust to get a full essay, order it on our website: BestEssayCheap.com
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